• Blood (Serum/ Plasma)
    Blood (Serum/ Plasma)

    Blood-based analysis for potential biomarkers has been an attractive domain over the last few years. While Cell-free DNA and Circulating Tumour Cells have been taking the front seats, there is growing interest in microRNA and methylated nucleic acids. Is microRNA the key to unlock the biological message from our body?

  • Urine, Saliva and Cerebrospinal Fluid
    Urine, Saliva and Cerebrospinal Fluid

    Leaping from minimal to non-invasive biomarker discovery, a handful of publications has identified key microRNA associated with metabolic disorders, bladder and prostate cancer in urine specimens. Selected studies have shown unique microRNA profiles in Saliva from respiratory-related infectious diseases to lung cancer.

  • Formaldehyde Fixed-Paraffin Embedded (FFPE)
    Formaldehyde Fixed-Paraffin Embedded (FFPE)

    Immunohistochemistry (IHC) staining has been a core technique in pathology labs to stratify tissue morphology. Recent advancement in molecular techniques have incorporated DNA analysis to provide better prognosis. The stability of microRNA in harsh formalin treatment presents an attractive option as a classifier.

  • Tissues & Cells
    Tissues & Cells

    Immortalized, primary or modified cell lines are often used by basic scientists to learn more about microRNA biology. Intervention methods such as knockdown, knockout, over-expression or genetically modified animals models are used downstream to validate findings.

  • Extracellular Vesicles - Exosomes
    Extracellular Vesicles - Exosomes

    Intercellular communication via extracellular vesicles(EV) has been of great interest over the last two decades. It is only in recent years, scientists gained new molecular tools to efficiently isolate and study them. A major breakthrough was the discovery that the cargo of EV included biologically significant mRNA, microRNA and proteins. The mechanisms and functions of these EVs remain unclear.